Preparation and Evaluation of Solid Dispersions of Aceclofenac
نویسندگان
چکیده
منابع مشابه
Preparation and Evaluation of Aceclofenac Topical Microemulsion
A topical preparation containing aceclofenac was developed using an o/w microemulsion system. Isopropyl myristate was chosen as the oil phase as it showed a good solubilising capacity. Pseudo-ternary phase diagrams were used to obtain the concentration ranges of the oil, surfactant (Labrasol) and co-surfactant (plurol oleique) for microemulsion formation. Five different formulations were formul...
متن کاملPreparation and Evaluation of Aceclofenac Topical Microemulsion
A topical preparation containing aceclofenac was developed using an o/w microemulsion system. Isopropyl myristate was chosen as the oil phase as it showed a good solubilising capacity. Pseudo-ternary phase diagrams were used to obtain the concentration ranges of the oil, surfactant (Labrasol) and co-surfactant (plurol oleique) for microemulsion formation. Five different formulations were formul...
متن کاملPreparation and evaluation of solid dispersions of cefpodoxime proxetil
Solid dispersions (SDs) are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. This technology is mainly applied to improve the solubility of Class II and Class IV drugs. Cefpodoxime proxetil (CP) is chosen as drug as it belongs to Class IV i. e. having low solubility and low permeability (Solubility: 400 μg/ml). SDs were prepared by using PV...
متن کاملEvaluation of anti-inflammatory, analgesic and immunosuppressant activities of aceclofenac solid dispersions on wistar rats
The present research work was focussed on the preparation as well as the evaluation of Aceclofenac solid dispersions for analgesic, anti-inflammatory and immunosuppressant activities. Solid dispersions were formulated using cros-carmellose sodium as polymer in different ratios. The solid dispersions were prepared using physical mixture, solvent evaporation and kneading techniques. The solid dis...
متن کاملA Modified Solvent Method for Preparation of Solid Dispersions
The first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using PEG 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. The second objective was to apply the modified solvent method for preparation of sustained re...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutical Sciences and Drug Research
سال: 2009
ISSN: 0975-248X
DOI: 10.25004/ijpsdr.2009.010108